Total synthesis of (±)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi

…, JA Smith, E Hamel, P Verdier-Pinard

文献索引：Banwell, Martin G.; Edwards, Alison J.; Jolliffe, Katrina A.; Smith, Jason A.; Hamel, Ernest; Verdier-Pinard, Pascal Organic and Biomolecular Chemistry, 2003 , vol. 1, # 2 p. 296 - 305

全文：HTML全文

被引用次数: 61

摘要

In 1998 Kam and co-workers reported on the isolation of the alkaloid (−)-rhazinal (1) from the stem extracts of a Malayan Kopsia species. 1 The compound had also been prepared by Vilsmeier–Haack formylation 2 of the closely related alkaloid (−)-rhazinilam (2), first isolated in 1965 from Melodinus australia, 3 then again in 1970 from Rhazya stricta (Apocynaceae) 4 and most recently (1987) from the Malaysian plant Kopsia singapurensis (Ridlay). 5 ...