Targeting carnitine biosynthesis: discovery of new inhibitors against γ-butyrobetaine hydroxylase

K Tars, J Leitans, A Kazaks, D Zelencova…

文献索引：Falzon, Cheryl L.; Ackermann, Uwe; Spratt, Neil; Tochon-Danguy, Henri J.; White, Jonathon; Howells, David; Scott, Andrew M. Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 12 p. 1089 - 1103

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被引用次数: 13

摘要

... J. Med. ... μM(9)). A recent study has linked the amount of plasma l-carnitine with levels of its metabolite, trimethylamine N-oxide, and the increased risk of cardiovascular and diabetic complications.(10, 11) To investigate new l-carnitine-lowering agents, a mildronate-like ...