2-氯乙醇

常用名 2-氯乙醇 英文名 2-chloroethanol
CAS号 107-07-3 分子量 80.513
密度 1.1±0.1 g/cm3 沸点 128.6±0.0 °C at 760 mmHg
分子式 C2H5ClO 熔点 -63 °C
MSDS2-氯乙醇的MSDS|SDS|pdf下载 中文版 美版

管制品

闪点 60.0±0.0 °C
符号 GHS02 GHS05 GHS06 GHS09
GHS02, GHS05, GHS06, GHS09
信号词 Danger

 2-氯乙醇用途


1.用作纤维素酯、涂料、树脂等的溶剂。也用于乙二醇、环氧乙烷、丙烯腈、医药、农药、染料等的制造以及用作甘蔗催芽剂等。

2. 用作溶剂,用于染料、农药、杀虫剂等有机合成。

3.用于制药、制革、合成表面活性剂、破乳剂及乳化剂中,还可生产环氧乙烷、乙二醇。在液体油墨中可作溶剂。

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 2-氯乙醇物理化学性质

[ 密度 ]: 1.1±0.1 g/cm3
[ 沸点 ]: 128.6±0.0 °C at 760 mmHg
[ 熔点 ]: -63 °C
[ 分子式 ]: C2H5ClO
[ 分子量 ]: 80.513
[ 闪点 ]: 60.0±0.0 °C
[ 精确质量 ]: 80.002892
[ PSA ]: 20.23000
[ LogP ]: -0.08
[ 外观性状 ]: 透明无色液体
[ 蒸汽密度 ]: 2.78 (vs air)
[ 蒸汽压 ]: 4.8±0.5 mmHg at 25°C
[ 折射率 ]: 1.417
[ 储存条件 ]:

1.储存于阴凉、干燥、通风良好的库房。远离火种、热源。保持容器密封。应与氧化剂、碱类、食用化学品分开存放,切忌混储。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。

2.一般用槽车运输,要避免撞击。也可用铁桶包装,每桶200kg。防止直接接触和蒸气外逸。按有毒物品规定贮运。

[ 稳定性 ]:

1.避免潮湿的空气。避免与强氧化剂、碱接触。可以燃烧,着火时用二氧化碳、四氯化碳、干式化学灭火剂灭火。受热分解生成剧毒的光气。与水或水蒸气反应生成有毒的腐蚀性气体。本品能渗透橡胶和树脂,应注意选择防护用品。

化学性质:2-氯乙醇具有氯和羟基两个官能团,因此表现出氯代烷和醇的性质。例如在碱存在下被氢还原,或用钠汞齐和水还原生成乙醇。用硝酸或铬酸氧化生成氯代乙酸。与水一起煮沸时逐渐水解生成乙二醇,添加碳酸氢钠对水解有促进作用。2-氯乙醇在氢氧化钠或石乳灰作用下,脱去氯化氢生成环氧乙烷。在封管中加热到184℃时生成1,2-二氯乙烷和乙醛。2-氯乙烷在浓硫酸存在下加热至90~100℃,发生分子间脱水生成双(2-氯乙基)醚。与伯胺、仲胺、芳香胺反应,生成相应的乙醇胺。与氨反应生成乙醇胺、二乙醇胺和三乙醇胺。与羧酸或酰氯反应生成羧酸-2-氯乙酯。与硫酰氯或磷酰氯反应容易生成磺酸或磷酸酯。在无水硫酸钠存在下与甲酸酐反应生成甲酸-2-氯乙酯。

2.有毒,在机体组织内水解产生氯化氢。吸入高浓度氯乙醇蒸气或者经皮肤接触而吸收,可引起呕吐、头痛、震颤、体温下降、四肢麻痹、心区疼痛而致死。多数情况下是在中毒之后经几小时才陷入危急状态。重症时开始有剧烈头痛,继而出现麻痹、腹泻、反复呕吐、口渴、眼灼热感,终至急性死亡。大鼠经口LD5095mg/kg.空气中大鼠LC32*10-6。工作场所空气中最高容许浓度5*10-6。为防止中毒,设备应密闭,生产现场要求通风良好,操作人员应戴好口罩、手套等防护用具。但橡皮手套不能起到保护作用,因为氯乙醇会透过橡皮手套与皮肤接触而造成危害。如果衣服上沾有氯乙醇应立即脱去,皮肤上沾有氯乙醇应用肥皂洗涤后,再用大量水冲洗。
 

[ 水溶解性 ]: MISCIBLE
[ 分子结构 ]:

1、 摩尔折射率:17.69

2、 摩尔体积(cm3/mol):70.4

3、 等张比容(90.2K):166.8

4、 表面张力(dyne/cm):31.5

5、 介电常数:

6、 偶极距(10-24cm3):

7、 极化率:7.01

[ 计算化学 ]:

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:1

3.氢键受体数量:1

4.可旋转化学键数量:1

5.互变异构体数量:无

6.拓扑分子极性表面积20.2

7.重原子数量:4

8.表面电荷:0

9.复杂度:10

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

[ 更多 ]:

1. 性状:无色透明液体。

2. 沸点(ºC,101.3kPa):128.8

3. 熔点(ºC):-67

4. 相对密度(g/mL,20/4ºC):1.2007

5. 相对蒸汽密度(g/mL,空气=1):2.78

6. 折射率(n20ºC):1.4421

7. 黏度(mPa·s,20ºC):3.4

8. 闪点(ºC,开口):60

9. 燃点(ºC):425

10. 蒸发热(KJ/mol,b.p.):41.45

11. 熔化热(KJ/mol):1215.0

12. 生成热(KJ/mol,液体):294.3

13. 燃烧热(KJ/mol,液体):1193.7

14. 爆炸下限(%,V/V):4.9

15. 爆炸上限(%,V/V):15.9

16. 蒸气压(kPa,30.3ºC):1.33

17. 体膨胀系数(K-1,55ºC):0.00092

18. 溶解性:能与水、丙酮、乙醚互溶,微溶于四氯化碳和烃类中。

19. 常温折射率(n25):1.4401

20. 相对密度(25℃,4℃):1.191230

21. 液相标准声称热(焓)( kJ·mol-1):-294.1

 2-氯乙醇MSDS

第一部分:化学品名称
化学品中文名称: 2-氯乙醇
化学品英文名称: 2-Chloroethanol
中文俗名或商品名:
Synonyms:
CAS No.: 107-07-3
分子式: C2H5ClO
分子量: 80.52
第二部分:成分/组成信息
纯化学品混合物
化学品名称:2-氯乙醇
有害物成分 含量 CAS No.
2-氯乙醇 100 107-07-3
第三部分:危险性概述
危险性类别:
侵入途径: 无资料
健康危害: 高浓度蒸气对眼、上呼吸道有刺激性。高浓度吸入出现头痛、头晕、嗜睡、恶心、呕吐,继之乏力、呼吸困难、紫绀、共济失调、抽搐、昏迷。重者发生脑和肺水肿。可因循环和呼吸衰竭而死亡。皮肤接触,可出现皮肤红斑;可经皮吸收引起中毒。口服可致死。慢性影响有头痛、乏力、胃纳减退、血压降低和消瘦等。
环境危害: 无资料
燃爆危险: 本品易燃,有毒,具刺激性。
第四部分:急救措施
皮肤接触: 立即脱去污染的衣着,用大量流动清水冲洗。就医。
眼睛接触: 提起眼睑,用流动清水或生理盐水冲洗。就医。
吸入: 迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难,给输氧。如呼吸停止,立即进行人工呼吸。就医。
食入: 饮足量温水,催吐。洗胃,导泄。就医。
第五部分:消防措施
危险特性: 其蒸气与空气可形成爆炸性混合物,遇明火、高热能引起燃烧爆炸。与氧化剂可发生反应。高热时能分解出剧毒的光气。遇水或水蒸气反应放热并产生有毒的腐蚀性气体。其蒸气比空气重,能在较低处扩散到相当远的地方,遇火源会着火回燃。若遇高热,容器内压增大,有开裂和爆炸的危险。
有害燃烧产物: 一氧化碳、二氧化碳、光气、氯化氢。
灭火方法及灭火剂: 泡沫、干粉、二氧化碳、砂土。
消防员的个体防护: 消防人员须佩戴防毒面具、穿全身消防服
禁止使用的灭火剂: 无资料
闪点(℃): 60
自燃温度(℃): 425
爆炸下限[%(V/V)]: 4.9
爆炸上限[%(V/V)]: 15.9
最小点火能(mJ):
爆燃点:
爆速:
最大燃爆压力(MPa):
建规火险分级:
第六部分:泄漏应急处理
应急处理: 迅速撤离泄漏污染区人员至安全区,并立即隔离150m,严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器,穿防毒服。尽可能切断泄漏源。防止流入下水道、排洪沟等限制性空间。小量泄漏:用砂土、蛭石或其它惰性材料吸收。也可以用大量水冲洗,洗水稀释后放入废水系统。大量泄漏:构筑围堤或挖坑收容。用泵转移至槽车或专用收集器内,回收或运至废物处理场所处置。
第七部分:操作处置与储存
操作注意事项: 密闭操作,提供充分的局部排风。操作人员必须经过专门培训,严格遵守操作规程。建议操作人员佩戴自吸过滤式防毒面具(半面罩),戴化学安全防护眼镜,穿防毒物渗透工作服,戴橡胶手套。远离火种、热源,工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂、碱类接触。搬运时要轻装轻卸,防止包装及容器损坏。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。
储存注意事项: 储存于阴凉、干燥、通风良好的库房。远离火种、热源。保持容器密封。应与氧化剂、碱类、食用化学品分开存放,切忌混储。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。
第八部分:接触控制/个体防护
最高容许浓度: 中国MAC:2mg/m3;前苏联MAC:0.5[皮]mg/m3 ;美国TWA:OSHA 5ppm,16.5mg/m3[皮],TLVWN: ACGIH 3.3mg/m3[皮][上限值]
监测方法: 无资料
工程控制: 严加密闭,提供充分的局部排风。提供安全淋浴和洗眼设备。
呼吸系统防护: 空气中浓度超标时,必须佩戴自吸过滤式防毒面具(半面罩)。紧急事态抢救或撤离时,应该佩戴空气呼吸器。
眼睛防护: 戴化学安全防护眼镜
身体防护: 穿防毒物渗透工作服。
手防护: 无资料
其他防护: 工作现场禁止吸烟、进食和饮水。工作完毕,彻底清洗。单独存放被毒物污染的衣服,洗后备用。注意个人清洁卫生。
第九部分:理化特性
外观与性状: 无色液体,微具醚香味。
pH:
熔点(℃): -67.5
沸点(℃): 128.8
相对密度(水=1): 1.20
相对蒸气密度(空气=1): 2.78
饱和蒸气压(kPa): 1.33(30.3℃)
燃烧热(kJ/mol):
临界温度(℃):
临界压力(MPa):
辛醇/水分配系数的对数值:
闪点(℃): 60
引燃温度(℃): 425
爆炸上限%(V/V): 15.9
爆炸下限%(V/V): 4.9
分子式: C2H5ClO
分子量: 80.52
蒸发速率:
粘性:
溶解性: 溶于水、酸、乙醚。
主要用途: 用于制造乙二醇、环氧乙烷,及医药、染料、农药的合成等。
第十部分:稳定性和反应活性
稳定性: 在常温常压下
禁配物: 碱、强氧化剂。
避免接触的条件: 无资料
聚合危害: 无资料
分解产物: 无资料
第十一部分:毒理学资料
急性毒性: LD50:71 mg/kg(大鼠经口);67 mg/kg(兔经皮) LC50:290 mg/m3(大鼠吸入)
急性中毒: 无资料
慢性中毒: 无资料
亚急性和慢性毒性:
刺激性: 无资料
致敏性:
致突变性:
致畸性:
致癌性:
第十二部分:生态学资料
生态毒理毒性: 无资料
生物降解性: 无资料
非生物降解性: 无资料
生物富集或生物积累性:
第十三部分:废弃处置
废弃物性质: 无资料
废弃处置方法: 用焚烧法处置。与燃料混合后,再焚烧。焚烧炉排出的卤化氢通过酸洗涤器除去。
废弃注意事项: 无资料
第十四部分:运输信息
危险货物编号: 61583
UN编号: 1135
包装标志:
包装类别:
包装方法: 小开口钢桶;安瓿瓶外普通木箱;螺纹口玻璃瓶、铁盖压口玻璃瓶、塑料瓶或金属桶(罐)外普通木箱;螺纹口玻璃瓶、塑料瓶或镀锡薄钢板桶(罐)外满底板花格箱、纤维板箱或胶合板箱。
运输注意事项: 运输前应先检查包装容器是否完整、密封,运输过程中要确保容器不泄漏、不倒塌、不坠落、不损坏。严禁与酸类、氧化剂、食品及食品添加剂混运。运输时运输车辆应配备相应品种和数量的消防器材及泄漏应急处理设备。运输途中应防曝晒、雨淋,防高温。运输时所用的槽(罐)车应有接地链,槽内可设孔隔板以减少震荡产生静电。中途停留时应远离火种、热源。公路运输时要按规定路线行驶。
RETCS号:
IMDG规则页码:
第十五部分:法规信息
国内化学品安全管理法规: 化学危险物品安全管理条例 (1987年2月17日国务院发布),化学危险物品安全管理条例实施细则 (化劳发[1992] 677号),工作场所安全使用化学品规定 ([1996]劳部发423号)等法规,针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定;常用危险化学品的分类及标志 (GB 13690-92)将该物质划为第6.1 类毒害品;车间空气中氯乙醇卫生标准 (GB 11524-89),规定了车间空气中该物质的最高容许浓度及检测方法。
国际化学品安全管理法规:
第十六部分:其他信息
参考文献:
填表时间: 2004年12月9日
填表部门: 无资料
数据审核单位: 无资料
修改说明: 无资料
其他信息:
MSDS修改日期: 1900年1月1日

 2-氯乙醇毒性和生态

2-氯乙醇毒理学数据:

1、急性毒性:大鼠经口LD50:95mg/kg;兔径皮LD50:67mg/kg

大鼠吸入LC50:290mg/m3

2、属中等毒类。对黏膜有较强刺激作用。2-氯乙醇可经呼吸道、皮肤、消化道进入肌体。急性中毒开始为头痛、头晕和消化道症状。数小时后转入狂躁兴奋状态,随即进入抑制状态,并出现昏迷和循环。呼吸衰竭。慢性中毒有头痛,乏力、黏膜刺激、食欲不振、消瘦等症状。工作场所最高容许浓度(美国)16mg/m3。

2-氯乙醇生态学数据:

该物质对水有稍微的危害。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KK0875000
CHEMICAL NAME :
Ethanol, 2-chloro-
CAS REGISTRY NUMBER :
107-07-3
BEILSTEIN REFERENCE NO. :
0878139
LAST UPDATED :
199712
DATA ITEMS CITED :
89
MOLECULAR FORMULA :
C2-H5-Cl-O
MOLECULAR WEIGHT :
80.52
WISWESSER LINE NOTATION :
Q2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
305 ppm/2H
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
71 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
290 mg/m3
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
293 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
84 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
71 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
81 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
385 mg/m3
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
97 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
98 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
91 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
67 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
870 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
85 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5670 mg/kg/12W-I
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in pituitary weight Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3400 mg/m3/15M/11D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration Blood - hemorrhage Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 mg/m3/4H/17W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
91 mg/kg/26W-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6188 mg/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
32500 mg/kg/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
384 mg/kg/30D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1152 mg/kg/12W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
910 mg/kg/26W-I
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1411 gm/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1154 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1932 mg/kg/15W-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1100 mg/kg
SEX/DURATION :
female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - hepatobiliary system
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-CL 3.3 mg/m3 (1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (16 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,108,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (16 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (16 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (16 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (16 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (3 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 1 ppm (3 mg/m3);Skin JAN 1993 OEL-BELGIUM:STEL 1 ppm (3.3 mg/m3);Skin JAN 1993 OEL-DENMARK:STEL 1 ppm (3 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 1 ppm (3 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 1 ppm (3 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 1 ppm (3 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (3 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 10 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWEDEN:STEL 1 ppm (3.5 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (3 mg/m3);STEL 5 ppm (15 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 5 ppm (16 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (3 mg/m3);STEL 1 ppm (3 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHYLENE CHLOROHYDRIN-air:CL 1 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4018 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 476 (estimated) No. of Female Employees: 68 (estimated)

 2-氯乙醇安全信息

[ 符号 ]: GHS02 GHS05 GHS06 GHS09
GHS02, GHS05, GHS06, GHS09
[ 信号词 ]: Danger
[ 危害声明 ]: H226-H290-H300 + H310 + H330-H318-H411
[ 警示性声明 ]: P210-P260-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310-P305 + P351 + P338 + P310-P403 + P233
[ 个人防护装备 ]: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]: T+:Verytoxic;
[ 风险声明 (欧洲) ]: R26/27/28
[ 安全声明 (欧洲) ]: S28-S45-S7/9-S28A-S36/37-S16-S7
[ 危险品运输编码 ]: UN 1135 6.1/PG 1
[ WGK德国 ]: 3
[ RTECS号 ]: KK0875000
[ 包装等级 ]: I
[ 危险类别 ]: 6.1
[ 海关编码 ]: 29333999

 2-氯乙醇合成线路

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 2-氯乙醇制备

1.氯乙醇有多种制备方法。环氧乙烷与盐酸反应,是实验室制备氯乙醇的最方便方法。实际上,乙二醇与二氯化硫反应得到氯乙醇,也是实验室制备氯乙醇的方法之一。如果环氧乙烷与无水氯化氢在氯化铁和磷酸二氢钠存在下反应,则无副产乙二醇生成,适用于制造高纯度氯乙醇。氯乙醇的工业生产方法基本上还是1991年Gomberg提出的方法,将乙烯和氯同时通入水中,氯与水反应生成次氯酸,次氯酸与乙烯加成即得氯乙醇。

107-07-3 preparation

107-07-3 preparation

2.精制方法:2-氯乙醇是由环氧乙烷和盐酸或氯的水溶液制备的。因此含有少量的酸和环氧乙烷衍生物。精制时用无水硫酸钠和无水碳酸钾脱水、脱酸后分馏。

3.以工业品32%的氯乙醇为原料,用苯进行恒沸蒸馏,进一步除去水分,再经减压蒸馏除去残留的苯和
高沸物,即得成品。
4.在氯化铁和磷酸二氢钠存在下,由无水氯化氢和环氧乙烷直接加
成,制得含量98%以上的2-氯乙醇

107-07-3 preparation

 2-氯乙醇海关

[ 海关编码 ]: 2905590020
[ 中文概述 ]: 2905590020 2-氯乙醇。监管条件:3(两用物项和技术出口许可证)A(两用物项和技术出口许可证,入境货物通关单)。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%
[申报要素 ]: 品名, 成分含量, 用途, 包装
[ 监管条件 ]: 3.两用物项和技术出口许可证 A.入境货物通关单
[ 检验检疫 ]: M.进口商品检验
[ Summary ]: 2905590020 2-chloroethanol。supervision conditions:3(export license for dual-use item and technologies)a(export license for dual-use item and technologies,certificate of inspection for goods inward)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:5.5%。general tariff:30.0%

 2-氯乙醇文献38

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