Facile TICl4-catalyzed synthesis of novel 1, 2, 4-triazoles appended to thiazoles

…, RK Hunnur, T Taj, MY Kariduraganavar

文献索引：Gireesh; Kamble; Hunnur; Taj; Kariduraganavar Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 7 p. 877 - 885

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被引用次数: 2

摘要

The reaction of sydnone-derived 3-aryl-5-methyl-1, 3, 4-oxadiazol-2 (3 H)-ones with thiourea and α-bromoacetophenone derivatives in the presence of a catalytic amount of TiCl 4 produces 2-aryl-4-(4-aryl-1, 3-thiazol-2-yl)-5-methyl-2, 4-dihydro-3 H-1, 2, 4-triazol-3-ones. The title compounds were screened for their antibacterial and antifungal activity. The toxicity of the compounds was evaluated in terms of mutagenicity, tumorigenicity, and ...