The Journal of Organic Chemistry

Synthesis of the dihydrodiol and diol epoxide metabolites of chrysene and 5-methylchrysene

RG Harvey, J Pataki, H Lee

文献索引：Harvey, Ronald G.; Pataki, John; Lee, Hongmee Journal of Organic Chemistry, 1986 , vol. 51, # 9 p. 1407 - 1412

全文：HTML全文

被引用次数: 49

摘要

Ronald G. Harvey,* John Pataki, and Hongmee Lee ... Ben May Laboratory, University of Chicago, Chicago, Illinois 60637 ... Carcinogenic polycyclic aromatic hydrocarbons are known to undergo enzymatic activation to diol epoxide metabolites bearing an epoxide ring in a bay molecular region. Introduction of a methyl group into a nonbenzo bay region position generally enhances carcinogenic activity. We now report efficient syntheses of the diastereomeric ...