The Journal of Organic Chemistry

Synthesis of the dihydrodiol and diol epoxide metabolites of chrysene and 5-methylchrysene

RG Harvey, J Pataki, H Lee

Index: Harvey, Ronald G.; Pataki, John; Lee, Hongmee Journal of Organic Chemistry, 1986 , vol. 51, # 9 p. 1407 - 1412

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Citation Number: 49

Abstract

Ronald G. Harvey,* John Pataki, and Hongmee Lee ... Ben May Laboratory, University of Chicago, Chicago, Illinois 60637 ... Carcinogenic polycyclic aromatic hydrocarbons are known to undergo enzymatic activation to diol epoxide metabolites bearing an epoxide ring in a bay molecular region. Introduction of a methyl group into a nonbenzo bay region position generally enhances carcinogenic activity. We now report efficient syntheses of the diastereomeric ...