Synthesis of Substituted Pyridines by a Cycloaddition Route Using Nitrile Oxides and Homoallyl Alcohols

S Kanemasa, Y Asai, J Tanaka

文献索引：Kanemasa Asai; Tanaka Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 375 - 380

被引用次数: 12

摘要

Cycloadditions of nitrile oxides with unprotected homoallyl alcohols, followed by Swern oxidations, lead to 5-(2-oxoalkyl)-2-isoxazolines. Subsequent Raney Ni reduction of the resulting heterocycles in ethanol in the presence of excess tetrafluoroboric acid affords substituted pyridine derivatives.

~53%

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~49%

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80735-94-0

1-苯基-3-丁烯-1-醇

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~39%

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~81%

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~96%

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~12%

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~60%

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~58%

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~50%

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