Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides

M Dolezal, P Cmedlova, L Palek, J Vinsova…

文献索引：Dolezal, Martin; Cmedlova, Pavlina; Palek, Lukas; Vinsova, Jarmila; Kunes, Jiri; Buchta, Vladimir; Jampilek, Josef; Kralova, Katarina European Journal of Medicinal Chemistry, 2008 , vol. 43, # 5 p. 1105 - 1113

全文：HTML全文

被引用次数: 57

摘要

Unsubstituted, halogenated and/or alkylated pyrazine-2-carboxylic acid amides connected via–CONH–bridge with substituted anilines were synthesized using currently known synthetic pathways. The synthetic approach, analytical, spectroscopic, lipophilicity and biological data of 20 newly synthesized compounds are presented. Structure–activity relationships among the chemical structures, the antimycobacterial, antifungal, ...