Synthesis and Antitubercular Evaluation of N??Arylpyrazine and N, N′??Alkyl??diylpyrazine??2??carboxamide Derivatives

MLF Bispo, RSB Gonçalves, CHS Lima…

文献索引：Bispo, Marcelle De Lima Ferreira; Goncalves, Raoni Schroeder Borges; Lima, Camilo Henrique Da Silva; Cardoso, Laura Nogueira De Faria; Lourenco, Maria Cristina Silva; De Souza, Marcus Vinicius Nora Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 6 p. 1317 - 1322

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被引用次数: 2

摘要

Abstract Two series of pyrazinamide (PZA) derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Some compounds exhibited minimum inhibitory concentration activity of 50–100 μg/mL, greater than the first line antituberculosis drug PZA in Alamar Blue assay (> 100 μg/mL). The obtained activities can be considered promising results, which characterizes these ...