Synlett

Formal asymmetric synthesis of a 7-methoxyaziridinomitosene

…, CB de Koning, TT Mudzunga, RL Petersen

文献索引：Michael, Joseph P.; De Koning, Charles B.; Mudzunga, Theophilus T.; Petersen, Riaan L. Synlett, 2006 , # 19 p. 3284 - 3288

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被引用次数: 7

摘要

Abstract The conversion of (-)-2, 3-O-isopropylidene-d-erythronolactone (14) and 2- benzyloxy-6-bromo-4-methoxy-3-methylaniline (18) into {(1R, 2R)-(-)-1-azido-2, 3, 5, 8- tetrahydro-7-methoxy-6-methyl-2-methanesulfonyloxy-5, 8-dioxo-1H-pyrrolo-[1, 2-a] indol-9- yl} methyl phenyl carbonate (39) has been accomplished in 17 steps by way of the enaminone 26. Key steps included the preparation of 26 by a Reformatsky reaction on a ...