Tripeptide LY301621 and its diastereomers as methicillin potentiators against methicillin resistant Staphylococcus aureus.

…, CJ SCHOFIELD, NJ WESTWOOD, L CHENG

文献索引：Eid, Clark N.; Halligan, Noreen G.; Nicas, Thalia I.; Mullen, Deborah L.; Butler, Thomas F.; Loncharich, Richard J.; Paschal, Jonathan W.; Schofield, Christopher J.; Westwood, Nicholas J.; Cheng, Leifeng Journal of Antibiotics, 1997 , vol. 50, # 3 p. 283 - 285

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被引用次数: 18

摘要

S. aureus (MRSA), wediscovered the unnatural tripeptide LY301621, 1 (Scheme 1). This unnatural tripeptide increases (potentiates) theactivity of methicillin against MRSA (Table 1). It is also a relatively weak stand-alone inhibitor of bacterial growth. Thesynthesis of thetitle compound1 is outlined in Scheme1. Alkylation of ethyl acetamidocyanoacetate anion with bromodiphenylmethane, followed by acid re-flux, affords racemicdiphenylalanine 9 (Dpa). ...