D-Phe-Pro-Arg-OH was synthesized by Neises and Turnudo with N, N-dibenzoylornithine as starting material through the Dakin-West reaction in a very complicated way due to the difficulty in removing the benzoyl groups. Arginine can not be used directly because of the drastic conditions used. For the preparation of a bifunctional inhibitor,~-Phe~-Arg $(COCH~) CH~ CO~~ hintdin-, Ac-D-Phe-Pro-A. rg $(COCHJGly-OH was synthesized from the ...
