Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11 C] hemicholinium-3 and [18 F] hemicholinium-3

…, R Nazih, MA Miller, TJ Receveur, JC Lopshire…

文献索引：Zheng, Qi-Huang; Gao, Mingzhang; Mock, Bruce H.; Wang, Shuyan; Hara, Toshihiko; Nazih, Rachid; Miller, Michael A.; Receveur, Tim J.; Lopshire, John C.; Groh, William J.; Zipes, Douglas P.; Hutchins, Gary D.; DeGrado, Timothy R. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2220 - 2224

全文：HTML全文

被引用次数: 29

摘要

The high-affinity choline transporter (CHT1) system is an attractive target for the development of positron emission tomography (PET) biomarkers to probe brain, cardiac, and cancer diseases. An efficient and convenient synthesis of new radiolabeled CHT1 inhibitors [11C] hemicholinium-3 and [18F] hemicholinium-3 by solid-phase extraction (SPE) technique using a cation-exchange CM Sep-Pak cartridge has been well developed. The ...