Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11 C] hemicholinium-3 and [18 F] hemicholinium-3

…, R Nazih, MA Miller, TJ Receveur, JC Lopshire…

Index: Zheng, Qi-Huang; Gao, Mingzhang; Mock, Bruce H.; Wang, Shuyan; Hara, Toshihiko; Nazih, Rachid; Miller, Michael A.; Receveur, Tim J.; Lopshire, John C.; Groh, William J.; Zipes, Douglas P.; Hutchins, Gary D.; DeGrado, Timothy R. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2220 - 2224

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Citation Number: 29

Abstract

The high-affinity choline transporter (CHT1) system is an attractive target for the development of positron emission tomography (PET) biomarkers to probe brain, cardiac, and cancer diseases. An efficient and convenient synthesis of new radiolabeled CHT1 inhibitors [11C] hemicholinium-3 and [18F] hemicholinium-3 by solid-phase extraction (SPE) technique using a cation-exchange CM Sep-Pak cartridge has been well developed. The ...