Catalytic asymmetric hydrogenation of 2, 3, 5-trisubstituted pyrroles

R Kuwano, M Kashiwabara, M Ohsumi…

文献索引：Kuwano, Ryoichi; Kashiwabara, Manabu; Ohsumi, Masato; Kusano, Hiroki Journal of the American Chemical Society, 2008 , vol. 130, # 3 p. 808 - 809

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被引用次数: 88

摘要

Catalytic asymmetric hydrogenation of N-Boc-protected pyrroles proceeded with high enantioselectivity by using a ruthenium catalyst modified with a trans-chelating chiral bisphosphine PhTRAP. The ruthenium catalyst prepared from Ru (η3-methallyl) 2 (cod) and (S, S)-(R, R)-PhTRAP in the presence of triethylamine was the most enantioselective for the asymmetric hydrogenation of methyl pyrrole-2-carboxylate, giving the desired (S)-proline ...