A General Procedure for Synthesis of NG??Alkyl, and NG??Aryl??L??Arginines as Potential Nitric Oxide Synthase inhibitors

BC Chen, S Shiu, DY Yang

文献索引：Chen, Bor-Cherng; Shiu, Shi; Yang, Ding-Yah Journal of the Chinese Chemical Society, 1998 , vol. 45, # 4 p. 549 - 553

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被引用次数: 3

摘要

Abstract A general procedure for the synthesis of N G-alkyl, and N G-aryl-L-arginines with relatively high overall yield is reported. The key step involved the coupling of protected L- ornithine 4 with isothiourea 7 to give the fully protected N G-aryl-L-arginine derivative 8. Subsequent deprotection of 8 in acidic condition provided the final target compound 9 with an overall yield of more than 80%.