Synthesis and QSAR studies in 2-(N-aryl-N-aroyl) amino-4, 5-dihydrothiazole derivatives as potential antithrombotic agents

AK Saxena, SK Pandey, P Seth, MP Singh…

文献索引：Saxena, Anil K.; Pandey, Suresh K.; Seth; Singh; Dikshit; Carpy Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2025 - 2034

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被引用次数: 24

摘要

A series of 2-(N-aryl-N-aroyl) amino-4, 5-dihydrothiazole derivatives have been synthesized via cyclocondensation of N-aryl thioureas with 2-bromoethylamine hydrobromide followed by the reaction of the product thus obtained with aroyl chlorides. Title compounds were evaluated for their antithrombotic activity in vivo in mice where one of these compound 29 provided 65% protection as compared to 77% protection offered by the standard ...