The solid phase synthesis of peptides containing an arginine residue with an unprotected guanidine group

YA Rubina, ZD Bespalova, VN Bushuev

文献索引：Rubina; Bespalova; Bushuev Russian Journal of Bioorganic Chemistry, 2000 , vol. 26, # 4 p. 235 - 244

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被引用次数: 4

摘要

Abstract A new variant of the solid phase synthesis of arginine-containing peptides was proposed. The conditions for the attachment to the Wang polymer of {ie235-1}-Fmoc- arginine containing a protonated guanidine group were found. We demonstrated that this attachment is accompanied by neither racemization nor the attachment of the second Arg residue. Side reactions involving the guanidine group of arginine were studied, and ...