Organic letters

Catalytic cyclopropanation of alkenes using diazo compounds generated in situ. A novel route to 2-arylcyclopropylamines

VK Aggarwal, J de Vicente, RV Bonnert

文献索引：Aggarwal, Varinder K.; De Vicente, Javier; Bonnert, Roger V. Organic Letters, 2001 , vol. 3, # 17 p. 2785 - 2788

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被引用次数: 90

摘要

A user-friendly, one-pot process for catalytic cyclopropanation of alkenes from tosylhydrazones is described. The cyclopropanation of N-vinylphthalimide provides a new route to 2-arylcyclopropylamines, and this is exemplified in the efficient synthesis of the HIV- 1 reverse transcriptase inhibitor 6.