Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes

GR Morais, HV Miranda, IC Santos, I Santos…

文献索引：Ribeiro Morais, Goreti; Vicente Miranda, Hugo; Santos, Isabel C.; Santos, Isabel; Outeiro, Tiago F.; Paulo, Antonio Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7698 - 7710

全文：HTML全文

被引用次数: 14

摘要

The formation of proteinaceous aggregates is a pathognomonic hallmark of several neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. To date, the final diagnostic for these diseases can only be achieved by immunostaining of post-mortem brain tissues with the commonly used congo red and Thioflavin T/S amyloid-dyes. The interest in developing amyloid-avid radioprobes to be used for protein aggregates ...