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Discovery, synthesis, and structure–activity relationship of 6-aminomethyl-7, 8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists

M Kamata, T Yamashita, T Imaeda, T Tanaka…

文献索引:Bioorganic and Medicinal Chemistry, , vol. 19, # 18 p. 5539 - 5552

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被引用次数: 9

摘要

... Bioorganic & Medicinal Chemistry. ... Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited ... 17 In the present report, we describe the details of our initial medicinal chemistry efforts starting from 1a, focusing especially on a distal phenyl ring, a core scaffold ...