Tetrahedron Letters

Synthesis of new series of iboga analogues

S Paul, S Pattanayak, S Sinha

文献索引：Paul, Sibasish; Pattanayak, Sankha; Sinha, Surajit Tetrahedron Letters, 2011 , vol. 52, # 46 p. 6166 - 6169

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被引用次数: 4

摘要

Synthesis of new iboga-analogues, replacing the indole ring with a benzofuran moiety has been described. Starting materials are the suitably substituted benzofuran derivatives and have been synthesized by Pd-catalyzed reactions. The conversion of endo-6- methylcarboxylate substituted dehydroisoquinuclidine to exo-isomer, a key component of iboga-alkaloids has been achieved in the presence of NaOMe in methanol under reflux ...