Synthesis of new iboga-analogues, replacing the indole ring with a benzofuran moiety has been described. Starting materials are the suitably substituted benzofuran derivatives and have been synthesized by Pd-catalyzed reactions. The conversion of endo-6- methylcarboxylate substituted dehydroisoquinuclidine to exo-isomer, a key component of iboga-alkaloids has been achieved in the presence of NaOMe in methanol under reflux ...
