Facile amine formation by intermolecular catalytic amidation of carbon-hydrogen bonds

…, S Trofimenko, MM Díaz-Requejo…

文献索引：Fructos, Manuel R.; Trofimenko, Swiatoslaw; Mar Diaz-Requejo; Perez, Pedro J. Journal of the American Chemical Society, 2006 , vol. 128, # 36 p. 11784 - 11791

全文：HTML全文

被引用次数: 190

摘要

A simple copper-based catalytic system has been developed for the carbon-hydrogen amidation reaction. The copper-homoscorpionate complex TpBr3Cu (NCMe) catalyzes the transfer of the nitrene unit NTs (Ts= p-toluenesulfonyl) and its subsequent insertion into the sp3 CH bonds of alkyl aromatic and cyclic ethers or the sp2 CH bonds of benzene using PhI NTs as the nitrene source, affording the corresponding trisubstitued NR1HTs amines in ...