Tetrahedron letters

Use of benzyloxycarbonyl (Z)-based fluorophilic tagging reagents in the purification of synthetic peptides

…, DJ van Zoelen, SP Oldfield, GA van der Marel…

文献索引：Filippov, Dmitri V.; Van Zoelen, Dirk J.; Oldfield, Steven P.; Van Der Marel, Gijs A.; Overkleeft, Herman S.; Drijfhout, Jan W.; Van Boom, Jacques H. Tetrahedron Letters, 2002 , vol. 43, # 43 p. 7809 - 7812

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被引用次数: 75

摘要

Three novel fluorous reagents (ie 1–3), derived from benzyl chloroformate (Z-Cl), have been synthesized and used for the tagging of peptides prepared following a Fmoc-based solid- phase approach. It is shown that the implementation of a benzyloxycarbonyl (Z)-based fluorophilic tag facilitates purification of peptides using fluorous reverse phase chromatography.