Fluorous synthesis of mono-dispersed poly (ethylene glycols)

…, H Zhang, F Yu, W Yu, G Xia, M Fu, Z Yang, ZX Jiang

文献索引：Li, Yu; Guo, Qi; Li, Xuefei; Zhang, Hua; Yu, Fanghua; Yu, Weijiang; Xia, Guiquan; Fu, Mingyang; Yang, Zhigang; Jiang, Zhong-Xing Tetrahedron Letters, 2014 , vol. 55, # 13 p. 2110 - 2113

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被引用次数: 11

摘要

Abstract Mono-dispersed poly (ethylene glycols)(PEGs) are of great value in the development of biopharmaceuticals. However, tedious synthesis limits the availability of mono-dispersed PEGs. To address this issue, a fluorous synthesis of mono-dispersed PEGs, discretely PEGylated surfactants and 19 F magnetic resonance imaging (MRI) agents has been developed. During the synthesis, both fluorous and normal phase silica gel-based ...