Tetrahedron: Asymmetry

Biotransformation of organic sulfides. Part 7. Formation of chiral isothiocyanato sulfoxides and related compounds by microbial biotransformation

HL Holland, FM Brown, BG Larsen, M Zabic

文献索引：Holland, Herbert L.; Brown, Frances M.; Larsen, Brett G.; Zabic, Mirjana Tetrahedron: Asymmetry, 1995 , vol. 6, # 7 p. 1569 - 1574

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被引用次数: 31

摘要

The fungi Helminthosporium species NRRL 4671 and Mortierella isabellina ATCC 42613 have been used for the biotransformation of a series of isothiocyanatoalkyl methyl sulfides and their synthetic precursors, ω-(methylthio) alkylphthalimides. H. species gave predominantly (S) sulfoxides in all cases; M. isabellina gave (R) isothiocyanatoalkyl methyl sulfoxides, but in the case of two ω-(methylthio) alkylphthalimides substantial conversion ...