Synthesis of bisindolylmaleimides using a palladium catalyzed cross-coupling reaction

DA Neel, MR Jirousek, JH McDonald

文献索引：Neel, David A.; Jirousek, Michael R.; McDonald III, John H. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 1 p. 47 - 50

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被引用次数: 35

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Bisindolylmaleimides are known to be potent and selective PKC inhibitors. A new synthesis of this class of compound is reported. The key step is a Suzuki cross-coupling reaction using a readily available indolylmaleimide triflate intermediate. ... Bisindolylmaleimides are ...