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Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation–cyclization cascade

S Zhu, DWC MacMillan

文献索引:Zhu, Shaolin; MacMillan, David W. C. Journal of the American Chemical Society, 2012 , vol. 134, # 26 p. 10815 - 10818

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被引用次数: 125

摘要

An enantioselective arylation–cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.