Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives

NSHN Moorthy, RJ Singh, HP Singh…

文献索引：Moorthy, Narayana Subbiah Hari Narayana; Singh, Rahul Jitendra; Singh, Hemendra Pratap; Gupta, Sayan Dutta Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 10 p. 1384 - 1390

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被引用次数: 28

摘要

Flavones chemically are anthoxanthins, occur either in the free state or as glycosides associated with tannins (flavanoids). Flavanoids (derivatives of flavone) possess various pharmacological activities and due to its xanthine-oxidase enzyme inhibitory effect it also has superoxide-scavenging activities. A series of 2-phenyl-2, 3-dihydrochromon-4-one derivatives (flavanone derivatives) were synthesized from chalcones by cyclization ...