European Journal of Organic Chemistry

Synthesis of Site??Specific Damaged DNA Strands by 8??(Acetylarylamino)??2′??deoxyguanosine Adducts and Effects on Various DNA Polymerases

S Krüger, C Meier

文献索引：Krueger, Sarah; Meier, Chris European Journal of Organic Chemistry, 2013 , # 6 p. 1158 - 1169

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被引用次数: 7

摘要

Abstract Beside the predominately found 8-(arylamino)-2′-dG, 8-(acetylarylamino) damages within DNA-strands may also play an important role in the induction of chemical carcinogenesis. A synthesis pathway leading to these 8-(acetylarylamino)-dG adducts using different aromatic amines has been optimized. The 8-modified dGs were converted into the corresponding phosphoramidites and site-specifically incorporated into different ...