Baker's Yeast Reduction of β??Hydroxy Ketones

D Acetti, E Brenna, C Fuganti, FG Gatti…

文献索引：Acetti, Daniela; Brenna, Elisabetta; Fuganti, Claudio; Gatti, Francesco G.; Serra, Stefano European Journal of Organic Chemistry, 2010 , # 1 p. 142 - 151

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被引用次数: 11

摘要

Abstract Reduction of β-hydroxy ketones to the corresponding 1, 3-diols by baker's yeast was investigated, in order to develop methods for simultaneous control over the configurations of multiple stereogenic centres. The reactions were found to be enantiospecific and generally characterised by good diastereoselectivity. Substrates with a substituent at the carbon atom in the α position were also considered. When the ...