Synthesis of “Trioxaquantel”® derivatives as potential new antischistosomal drugs

…, H Gornitzka, A Robert, B Meunier

文献索引：Laurent, Sophie A.-L.; Boissier, Jerome; Cosledan, Frederic; Gornitzka, Heinz; Robert, Anne; Meunier, Bernard European Journal of Organic Chemistry, 2008 , # 5 p. 895 - 913

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被引用次数: 44

摘要

Abstract Over the past 20 years, praziquantel, a pyrazinoisoquinoline derivative, has become the mainstay for morbidity control of human and animal schistosomiasis. From early in their lives in vertebrate hosts, schistosomes ingest hemoglobin and aggregate the released heme as a dark pigment very similar to the hemozoin produced by Plasmodium in malaria infection. The antimalarial artemisinin derivatives have real, though low, ...