European journal of medicinal chemistry

Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents

HM Aly, NM Saleh, HA Elhady

文献索引：Aly, Hala M.; Saleh, Nashwa M.; Elhady, Heba A. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4566 - 4572

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被引用次数: 43

摘要

4-acetamide pyrazolone 2 was synthesized by acetylation of 4-amino antipyrine 1 in excellent yield. 4-acetamide pyrazolone 2 was exploited as a starting material for the syntheses of hitherto unknown different types of new heterocyclic compounds incorporating the antipyrine moiety which expect highly biological activity against various microorganisms. Thus, Claisen condensation of 4-acetamide pyrazolone 2 with diethyl oxalate have been ...