Synthesis of possible metabolites of chlorpromazine. V. 3, 7??Disubstituted chlorpromazine derivatives

EA Nodiff, T Hayazaki, T Ito, HL Sharma…

文献索引：Nodiff,E.A. et al. Journal of Heterocyclic Chemistry, 1971 , vol. 8, p. 1075 - 1078

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被引用次数: 4

摘要

The oxidation of phenothiazine to phenothiazone with ferric chloride in dilute acetic acid was described by Bodea and Raileanu (8). Scheme 4 sketches our attempts to apply this method to the preparation of the alkoxyphenothiazones, XXV, XXVI, XXX and XXXI, from the corresponding alkoxyphenothiazines, XXI11, XXIV, XXVIII and XXIX. Instead of the desired reaction, oxidative dealkylation occurred, with formation of the phenothiazones, XXI and ...