Tandem Blaise/retro-Blaise reaction for the nitrile-mediated regioselective intermolecular addition of unstabilized zinc ester enolates (Reformatsky reagents) to 1- …
JH Kim, YS Chun, S Lee
文献索引：Kim, Ju Hyun; Chun, Yu Sung; Lee, Sang-Gi Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11483 - 11493
We report the novel use of a nitrile as a mediator to achieve the regioselective intermolecular addition of unstabilized zinc ester enolates (Reformatsky reagents) to 1- alkynes and 1, 3-enynes. This reaction is made possible by a reversible addition of enolates to a nitrile (Blaise reaction), generating a zinc aza-enolate that, unlike zinc ester enolates, can add intermolecularly to 1-alkynes and 1, 3-enynes. Subsequent removal of the nitrile ...
