Tetrahedron Letters

Multi-gram scale mercury-free synthesis of optically pure 3, 4, 5-trisubstituted 1, 2, 4-triazoles using silver benzoate

M Bibian, AL Blayo, A Moulin, J Martinez, JA Fehrentz

文献索引：Bibian, Mathieu; Blayo, Anne-Laure; Moulin, Aline; Martinez, Jean; Fehrentz, Jean-Alain Tetrahedron Letters, 2010 , vol. 51, # 19 p. 2660 - 2663

全文：HTML全文

被引用次数: 17

摘要

We report a new method using silver benzoate instead of mercury salts as a key reagent for the synthesis of 3, 4, 5-trisubstituted 1, 2, 4-triazoles. This method allows the introduction of a large variety of substituents in the three positions. We demonstrated that we could introduce one chiral center without any loss of the optical purity. This method is compatible with at least multi-gram scale-up.