Free radical addition of trichloromethyl to caffeine access to C-8 polyhalogenoalkane derivatives and to unexpected 5-trichloromethyl-1, 3, 7 trimethyl-5, 7-dihydrouric …
J Zylber, N Zylber, A Chiaroni, C Riche
文献索引：Zylber, Jean; Zylber, Nicole; Chiaroni, Angele; Riche, Claude Tetrahedron Letters, 1984 , vol. 25, # 35 p. 3853 - 3856
Abstract The “Electrophilic” trichloromethyl radical was introduced directly into the model purine compound, caffeine, leading to products 2 and 3 (the former being smoothly converted to the corresponding carboxy ester derivative) and to the unexpected C-5 substituted title compound 4.
