A synthetic route to highly substituted ketones. Acylations of. alpha. anions of carboxylic acid salts with acid chlorides

AP Krapcho, DS Kashdan…

文献索引：Krapcho,A.P. et al. Journal of Organic Chemistry, 1977 , vol. 42, p. 1189 - 1194

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被引用次数: 22

摘要

A solution made from dissolving 0.58 g (0.02 mol) of sodium in 50 ml of anhydrous methanol was added to the hexabromide and the mixture refluxed for 2 h. At the end of the refluxing period, the solution was filtered and solvent removed in vacuo to yield an oil which solidified overnight. The residue was dissolved in 25 ml of dioxane, and 75 ml of water and 5 ml of concentrate hydrogen chloride were added to the stirring solution. The resulting cloudy ...