De Novo Design, Synthesis and Evaluation of Benzylpiperazine Derivatives as Highly Selective Binders of Mcl??1

…, M Zhou, L Han, Z Zhang, Q Ba, J Li, H Wang…

文献索引：Ding, Xiao; Li, Yan; Lv, Li; Zhou, Mi; Han, Li; Zhang, Zhengxi; Ba, Qian; Li, Jingquan; Wang, Hui; Liu, Hong; Wang, Renxiao ChemMedChem, 2013 , vol. 8, # 12 p. 1986 - 2014

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被引用次数: 9

摘要

Abstract Considerable efforts have been made to the development of small-molecule inhibitors of antiapoptotic B-cell lymphoma 2 (Bcl-2) family proteins (such as Bcl-2, Bcl-x L, and Mcl-1) as a new class of anticancer therapies. Unlike general inhibitors of the entire family, selective inhibitors of each member protein can hopefully reduce the adverse side effects in chemotherapy treatments of cancers overexpressing different Bcl-2 family ...