Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors

F Mutulis, I Mutule, M Lapins, JES Wikberg

文献索引：Mutulis, Felikss; Mutule, Ilze; Lapins, Maris; Wikberg, Jarl E.S. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1035 - 1038

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被引用次数: 27

摘要

Presumed pharmacophoric groups of melanocortin peptides (naphthalene, amino or guanidine, and indole moieties) were combined in mimetics molecules looking for their favorable location for activity at melanocortin (MC) receptors. Twenty-two compounds were prepared and tested. The best of these displayed micromolar affinities for the MC receptors.