A novel series of potent and selective small molecule inhibitors of the complement component C1s

NL Subasinghe, F Ali, CR Illig, MJ Rudolph…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 12 p. 3043 - 3047

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被引用次数: 17

摘要

... Bioorganic & Medicinal Chemistry Letters. ... The bromomethylketones required to accesses 3-O-alkyl-containing pyrazoles (50–52) were synthesized via Mitsunobu chemistry according to Scheme 3. 22 The commercially available pyrazole 43 was alkylated under Mitsunobu ...