Synthesis of 5??substituted 1??aryl??1H??pyrazole??4??acetonitriles, 4??methyl??1??phenyl??1H??pyrazole??3??carbonitriles and pharmacologically active 1??aryl??1H??pyrazole??4 …

G Menozzi, P Schenone, L Mosti…

文献索引：Menozzi; Schenone; Mosti; Mattioli Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 997 - 1002

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被引用次数: 29

摘要

Abstract Lithium aluminum hydride reduction of 5-substituted or unsubstituted ethyl or methyl 1-aryl-1H-pyrazole-4-carboxylates gave, generally in excellent yields, 5-substituted or unsubstituted 1-aryl-1H-pyrazole-4-methanols which afforded the corresponding 1-aryl-4- (bromomethyl)-1H-pyrazoles with hydrobromic acid in acetic acid solution. These crude intermediates gave by reaction with potassium cyanide in dimethylsulfoxide solution 1-aryl ...