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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Cardiac-slowing amidines containing the 3-thioindole group. Potential antianginal agents

MJ Zelesko, DF McComsey, WE Hageman…

文献索引：Zelesko, Michael J.; McComsey, David F.; Hageman, William E.; Nortey, Samuel O.; Baker, Carol A.; Maryanoff, Bruce E. Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 230 - 237

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被引用次数: 10

摘要

Scheme I. Indole I was reacted with thiourea and Iz/KI, and the thiouronium intermediate product was immediately hydrolyzed with aqueous NaOH to give sodium 3-indolylthiolate I1 in situ.'l The thiolate was alkylated with chloroacetonitrile to give nitrile 111. If desired, N- alkylation could be conducted at this point by reaction of nitrile I11 with an alkyl halide and aqueous NaOH, giving alkylated nitriles IV. Reduction of I11 or IV with BH3. THFlZ or ...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-[1-(2-methoxyethyl)indol-3-yl]sulfanylacetonitrile结构式

2-[1-(2-methoxy...

吲哚结构式

~%

2-[1-(2-methoxyethyl)indol-3-yl]sulfanylacetonitrile结构式

2-[1-(2-methoxy...

2-(1H-吲哚-3-磺酰基)-乙胺结构式

2-(1H-吲哚-3-磺酰基)-乙胺

5-ethoxy-1-methyl-3,4-dihydro-2H-pyrrolium, tetrafluoroborate结构式

5-ethoxy-1-meth...

~40%

N-[2-(1H-indol-3-ylsulfanyl)ethyl]-1-methylpyrrolidin-2-imine结构式

N-[2-(1H-indol-...

3-(1H-indol-3-ylsulfanyl)propan-1-amine结构式

3-(1H-indol-3-y...

5-ethoxy-1-methyl-3,4-dihydro-2H-pyrrolium, tetrafluoroborate结构式

5-ethoxy-1-meth...

~%

N-[3-(1H-indol-3-ylsulfanyl)propyl]-1-methylpyrrolidin-2-imine结构式

N-[3-(1H-indol-...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-[1-(cyclopropylmethyl)indol-3-yl]sulfanylacetonitrile结构式

2-[1-(cycloprop...

吲哚结构式

~%

2-[1-(cyclopropylmethyl)indol-3-yl]sulfanylacetonitrile结构式

2-[1-(cycloprop...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-(1-octylindol-3-yl)sulfanylacetonitrile结构式

2-(1-octylindol...

吲哚结构式

~%

2-(1-octylindol-3-yl)sulfanylacetonitrile结构式

2-(1-octylindol...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-[1-(furan-2-ylmethyl)indol-3-yl]sulfanylacetonitrile结构式

2-[1-(furan-2-y...

吲哚结构式

~%

2-[1-(furan-2-ylmethyl)indol-3-yl]sulfanylacetonitrile结构式

2-[1-(furan-2-y...

吲哚结构式

~%

3-(1H-indol-3-ylsulfanyl)propan-1-amine结构式

3-(1H-indol-3-y...

2-((5-chloro-2-methyl-1H-indol-3-yl)thio)acetonitrile结构式

2-((5-chloro-2-...

~%

2-[(5-chloro-2-methyl-1H-indol-3-yl)sulfanyl]ethanamine结构式

2-[(5-chloro-2-...

5-氯-2-甲基吲哚结构式

5-氯-2-甲基吲哚

~%

2-[(5-chloro-2-methyl-1H-indol-3-yl)sulfanyl]ethanamine结构式

2-[(5-chloro-2-...

5-甲氧基吲哚结构式

5-甲氧基吲哚

~%

2-[(5-methoxy-1H-indol-3-yl)sulfanyl]acetonitrile结构式

2-[(5-methoxy-1...

2-甲基吲哚结构式

~%

2-[(2-methyl-1H-indol-3-yl)sulfanyl]acetonitrile结构式

2-[(2-methyl-1H...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-(1H-吲哚-3-磺酰基)-乙胺结构式

2-(1H-吲哚-3-磺酰基)-乙胺

吲哚结构式

~%

2-(1H-吲哚-3-磺酰基)-乙胺结构式

2-(1H-吲哚-3-磺酰基)-乙胺

5-氯吲哚结构式

~%

2-[(5-chloro-1H-indol-3-yl)sulfanyl]acetonitrile结构式

2-[(5-chloro-1H...

5-乙基-1H-吲哚结构式

5-乙基-1H-吲哚

~%

2-[(5-ethyl-1H-indol-3-yl)sulfanyl]acetonitrile结构式

2-[(5-ethyl-1H-...

吲哚结构式

~%

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-(1-methylindol-3-yl)sulfanylacetonitrile结构式

2-(1-methylindo...

吲哚结构式

~%

2-(1-methylindol-3-yl)sulfanylacetonitrile结构式

2-(1-methylindo...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

烯丙基溴结构式

~85%

2-(1-prop-2-enylindol-3-yl)sulfanylacetonitrile结构式

2-(1-prop-2-eny...

吲哚结构式

~%

2-(1-prop-2-enylindol-3-yl)sulfanylacetonitrile结构式

2-(1-prop-2-eny...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-(1-prop-2-ynylindol-3-yl)sulfanylacetonitrile结构式

2-(1-prop-2-yny...

吲哚结构式

~%

2-(1-prop-2-ynylindol-3-yl)sulfanylacetonitrile结构式

2-(1-prop-2-yny...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-[1-(2-methylprop-2-enyl)indol-3-yl]sulfanylacetonitrile结构式

2-[1-(2-methylp...

吲哚结构式

~%

2-[1-(2-methylprop-2-enyl)indol-3-yl]sulfanylacetonitrile结构式

2-[1-(2-methylp...

吲哚结构式

~%

4-(1H-indol-3-ylsulfanyl)butanenitrile结构式

4-(1H-indol-3-y...

4-(1H-indol-3-ylsulfanyl)butanenitrile结构式

4-(1H-indol-3-y...

~%

4-(1H-indol-3-ylsulfanyl)butan-1-amine结构式

4-(1H-indol-3-y...

吲哚结构式

~%

4-(1H-indol-3-ylsulfanyl)butan-1-amine结构式

4-(1H-indol-3-y...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-(1-ethylindol-3-yl)sulfanylacetonitrile结构式

2-(1-ethylindol...

吲哚结构式

~%

2-(1-ethylindol-3-yl)sulfanylacetonitrile结构式

2-(1-ethylindol...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-(1-propan-2-ylindol-3-yl)sulfanylacetonitrile结构式

2-(1-propan-2-y...

吲哚结构式

~%

2-(1-propan-2-ylindol-3-yl)sulfanylacetonitrile结构式

2-(1-propan-2-y...

2-[(2-methyl-1H-indol-3-yl)sulfanyl]acetonitrile结构式

2-[(2-methyl-1H...

~%

2-(1,2-dimethylindol-3-yl)sulfanylacetonitrile结构式

2-(1,2-dimethyl...

2-甲基吲哚结构式

~%

2-(1,2-dimethylindol-3-yl)sulfanylacetonitrile结构式

2-(1,2-dimethyl...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-(1-cyclopentylindol-3-yl)sulfanylacetonitrile结构式

2-(1-cyclopenty...

吲哚结构式

~%

2-(1-cyclopentylindol-3-yl)sulfanylacetonitrile结构式

2-(1-cyclopenty...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-(1-propylindol-3-yl)sulfanylacetonitrile结构式

2-(1-propylindo...

吲哚结构式

~%

2-(1-propylindol-3-yl)sulfanylacetonitrile结构式

2-(1-propylindo...

2-(1H-indol-3-ylsulfanyl)acetonitrile结构式

2-(1H-indol-3-y...

~%

2-(1-benzylindol-3-yl)sulfanylacetonitrile结构式

2-(1-benzylindo...

吲哚结构式

~%

2-(1-benzylindol-3-yl)sulfanylacetonitrile结构式

2-(1-benzylindo...

2-[(2-methyl-1H-indol-3-yl)sulfanyl]acetonitrile结构式

2-[(2-methyl-1H...

~%

2-[(2-METHYL-1H-INDOL-3-YL)THIO]ETHANAMINE结构式

2-[(2-METHYL-1H...

2-甲基吲哚结构式

~%

2-[(2-METHYL-1H-INDOL-3-YL)THIO]ETHANAMINE结构式

2-[(2-METHYL-1H...