A new bactericidal lead structure for the protection of materials

…, J Kaulen, M Kugler, P Wachtler, W Kreiss…

文献索引：Vogl, Erasmus; Bruns, Rainer; Kretschik, Oliver; Uhr, Hermann; Kaulen, Johannes; Kugler, Martin; Wachtler, Peter; Kreiss, Wolfgang; Eberz, Guenther Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 625 - 629

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被引用次数: 7

摘要

Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100ppm but unfortunately increases the number of mutations in Ames tests.