Abstract The aromatic nucleus of hemicholinium-3 was replaced with an aliphatic hexa- methylene chain without loss of the characteristic pharmacological activity. The toxic dose was elevated in mice about tenfold by the change. Choline chloride was a very effective antidote to intoxication from the aliphatic hemicholinium. Another compound synthesized, a pyridine analog, had marked anticholinesterase activity, but caused a flaccid paralysis in ...
