Anticonvulsants. II. Spiro Compounds. Dibenzo [α, d] cycloheptadiene-5, 5'-hydantoins,-5, 5'-oxazolidinediones, and-5, 2'-succinimides

MA Davis, SO Winthrop, RA Thomas…

文献索引：Davis,M.A. et al. Journal of Medicinal Chemistry, 1964 , vol. 7, p. 439 - 445

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被引用次数: 11

摘要

Spiro (dibenxo [a, d] cgcloheptadiene-5~ 5'-hydantoin)(IIa), an analog of diphenylhydantoin, was prepared by the rearrangement, of dibenzo [a, e] cyclooctadiene-5, 6-dione (111) wit'h urea and alkali and by heating 5-hydroxy-dibenzo [a, d] cycloheptadiene-5-carboxplic acid (VII, R= H) with urea alone. Substitution of thiourea in the first, method gave the corresponding spirothiohydantoin (17) which was then converted to the desthio ...