Perfluoro-N-[4-(1H-tetrazol-5-ylmethyl) phenyl] alkanamides. A new class of oral antidiabetic agents

KL Kees, RS Cheeseman, DH Prozialeck…

文献索引：Kees; Cheeseman; Prozialeck; Steiner Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 11 - 13

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被引用次数: 31

摘要

The withdrawal of the biguanides from the US. market in 1977 has left only one class of oral hypoglycemic agent, the sulfonylureas, for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) in this country.'Despite an improvement of 250-fold in potency over the last 33 years (eg glibenclamide), the sulfonylureas are still afflicted with the serious and sometimes fatal problem of drug-induced hypoglycemia, 2 apparently the result of ...