Perfluorocarbon-based antidiabetic agents

…, TM Smith, ML McCaleb, DH Prozialeck…

文献索引：Kees; Smith; McCaleb; Prozialeck; Cheeseman; Christos; Patt; Steiner Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 944 - 953

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被引用次数: 22

摘要

In a preliminary communication (J. Med. Chem. 1989, 32, 11-13) a series of perfluoro-N-[4- (1H-tetrazol-5yl-methy1) phenyllalkanamides (perfluoro anilides I), designed as novel analogues of ciglitazone, were reported to possess oral antidiabetic activity in two genetic animal models of non-insulin-dependent diabeh mellitus (NIDDM): obese (ob/ob) and diabetic (db/db) mice. In this report, the results from a structure-activity relationship (SAR) ...