Triazino indole–quinoline hybrid: A novel approach to antileishmanial agents

…, AK Pandey, R Shivahare, K Srivastava…

文献索引：Sharma, Rashmi; Pandey, Anand Kumar; Shivahare, Rahul; Srivastava, Khushboo; Gupta, Suman; Chauhan, Prem M.S. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 298 - 301

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被引用次数: 15

摘要

Abstract A novel series of 1, 2, 4-triazino-[5, 6b] indole-3-thione covalently linked to 7-chloro- 4-aminoquinoline have been synthesized and evaluated for their in vitro activity against extracellular promastigote and intracellular amastigote form of Leishmania donovani. Among all tested compounds, compounds 7a and 7b were found to be the most active with IC 50 values 1.11, 0.36 μM and selectivity index (SI) values 67,> 1111, respectively, ...